Abstract
Urine sepsis is a complex inflammatory response of the body to infection with a high fatality rate. It is one of the main causes of death in noncardiovascular intensive care units. Nevertheless, in daily clinical practice, early sepsis is often not detected. In this paper, discharged cases of urinary sepsis from the Department of Urology and Critical Care Medicine of a university hospital were collected as the observation group, and common urinary tract infection cases were selected as the control group. We sorted and summarized the discharged case information of the observation group and the control group. The results of the study showed that, after renal pelvis perfusion, the expression of HMGB1 protein and mRNA increased, and the expression of TLR4 increased; inhibiting HMGB1 can reduce the expression of inflammatory factors caused by perfusion and reduce the infiltration of neutrophils and macrophages caused by perfusion. In addition, r HMGB1 treatment can promote the expression of inflammatory factors caused by perfusion and aggravate the infiltration of neutrophils and macrophages caused by perfusion. We found that inhibition of HMGB1 can inhibit the expression of TLR4/My D88 signaling molecules and r HMGB1 treatment can enhance the expression of TLR4/My D88 signaling molecules.
Highlights
Urinary calculi are a very common clinical disease
If timely and effective treatment is not given, it may even progress to urinary sepsis, which endangers the life of the patient. erefore, it is clear that the related factors and independent risk factors for urosepsis after percutaneous nephrolithotomy (PNL) and corresponding prevention and treatment before and after surgery can effectively reduce the incidence of urosepsis after surgery, ensure the efficacy of surgery, and improve the quality of patient prognosis [6, 7]
Blood routine, urine routine, C-reactive protein (CRP), and other inflammatory indicators are the main monitoring methods. e abnormal percentage of neutrophils in routine blood tests can indicate the presence of urinary tract infections, but the specificity of disease diagnosis is low, and other diagnostic indicators need to be combined to determine the site of infection, and the value of determining the severity of infection is limited. e test results of each group in this study showed that the percentage of neutrophils was generally increased, and the severity of urinary tract infection was related to the age of the patients
Summary
Urinary calculi are a very common clinical disease. The clinical incidence of this disease in my country has shown an upward trend [1]. E incidence of postoperative complications of PNL can reach about 29% to 80%. If timely and effective treatment is not given, it may even progress to urinary sepsis, which endangers the life of the patient. Erefore, it is clear that the related factors and independent risk factors for urosepsis after PNL and corresponding prevention and treatment before and after surgery can effectively reduce the incidence of urosepsis after surgery, ensure the efficacy of surgery, and improve the quality of patient prognosis [6, 7] If timely and effective treatment is not given, it may even progress to urinary sepsis, which endangers the life of the patient. erefore, it is clear that the related factors and independent risk factors for urosepsis after PNL and corresponding prevention and treatment before and after surgery can effectively reduce the incidence of urosepsis after surgery, ensure the efficacy of surgery, and improve the quality of patient prognosis [6, 7]
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