Abstract
AIM:To investigate the expression of inducible NOS (iNOS) in human gastric cancer and its relationship with the angiogenesis in gastric cancer and lymphocyte metastasis. METHODS:The expression of iNOS in 50 patients with gastric cancer was studied by immunohistochemical SP method with anti-iNOS. Microvessel density (MVD) of human gastric cancer was also determined with anti-CD34 as the labels. RESULTS:The expression rate of iNOS in 50 cases was 70 %, and the rates of node negative and node positive in gastric cancer were 54.2 % and 84.6 %,respectively, with significant difference (P <0.01). There was a significant difference of MVD (P <0.01) among groups with different expression of iNOS. CONCLUSION:The expression rate of iNOS in human gastric cancer is high, and it is closely related to the carcinoangiogenesis and metastasis.
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