Abstract
ESb, a cellular high metastatic variant derived from the murine T-cell lymphoma L5178Y (Eb), was found to synthesize la antigens. Ia-specific antibodies reacted with the ESb cells and precipitated Ia-like molecules from them. Two-dimensional gel electrophoretic analysis of immunoprecipitates of metabolically labeled ESb cells indicated that the la molecules on ESb were indistinguishable from those on murine B-cells. No la antigens were detectable on the parental tumor line Eb. Treatment with recombinant interferon-γ (IFN-γ) caused enhancement of class I histocompatibility antigen expression on Eb and ESb tumor lines. In ESb cells the expression of la and of Ia-associated invariant chain (Ii) was also increased upon IFN-γ treatment. No induction of either la and li antigens was observed upon IFN-γ treatment of the Eb line. These studies demonstrate a substantial difference between the Eb and ESb tumor lines with respect to: (i) constitutive expression of class II major histocompatibility antigens, and (ii) response to IFN-γ treatment.
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