Abstract
Objective To observe the expression of human leukocyte antigen I （ HLA I） and anti- gen processing machinery （APM） components, and their correlation with pathological grading. Methods Forty-one tumor sections from forty-one glioma patients were examined by using immunohistochemistry. The expression of HLA I antigen and APM components was detected, and their correlation with the pathological grading was analyzed. Results Frequency of HLA I antigen loss in dedicated groups was 11%, 25% , 30% and 40% , respectively. There was a positive correlation between the expression levels of transporter associated with antigen processing （TAP） 1 and TAP2 with glioma pathological grading （P 〈 0.05）. Additionally, there was a positive correlation between TAP1 and TAP2 level （P 〈 0.05）. Conclusion The level of HLA I antigen and most of APM components expression is decreased with the increase in tumor patho-logical grade, which may explain the phenomenon that glioma cells frequently escape from immunological surveillance or immunotherapy. Key words: Glioma; Antigen processing; Pathological grading
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