Expression of HSF2 in ulcerative colitis and other intestinal diseases

Abstract

Objective To investigate the expression of HSF2 in colonic mucosa of patients with ul- cerative colitis （UC）, Crohn＇s disease （ C D）, intestinal tuberculosis （ ITB）, intestinal lymphoma （ IL）, infectious enteritis, Behcetg disease and normal control. Methods Intestinal tissue samples were retrieved from 2003 -2011 archived specimen at the Department of Pathology, and assigned to UC group （n = 38 ）, CD group （n =29）, ITB group （n =31 ）, IL group （n =32）, infectious enteritis group （n =32） and Beh- cet＇s disease group （n =28）. 10 cases were recruited as normal control group. The expression of HSF2 in colonic mucosa were detected by immunohistochemistry. Positive cells were counted by Image Analysis. Re- suits The expression rate of HSF2 in intestinal mucosa of UC patients （ 64. 64 ±15.17 ） was significantly higher than that of CD （ 32.44± 5.94 ）, ITB （ 36. 93 ±6. 32 ）, IL （ 36. 16 ±6. 55 ）, infectious enteritis （37.86 ±7. 76）, Behcet＇s disease （34. 90 ±5.92） and normal control （35.54 ±6. 76） （P 〈0. 05）, while there was no significant difference among the latter six groups （ P 〉 0. 05 ）. Conclusion HSF2 is closely re- lated with UC, and may play an important role in the pathogenesis, diagnosis and differential diagnosis of UC. Key words: Ulcerative colitis ; Heat shock factor 2 ; Immunohistochemistry