Abstract
Objective To investigate protein levels of histone deacetylase 1 ( HDAC1 ) in low grade and high grade of astrocytomas and its correlation with clinical prognosis of astrocytomas.Methods Samples from 283 primary gliomas of WHO Ⅱ -Ⅳ and 52 recurrent lesions were evaluated.The histopathologic diagnoses were as follows:59 cases of low-grade gliomas ( grade Ⅱ) and 276 cases of high-grade gliomas (26 grade Ⅲ and 250 glioblastomas).The expression of HDAC1 was immunohistochemically analyzed and its correlation with tumor differentiation,tumor proliferation and survival was analyzed.Results Totally 59.6％ of the tumors showed HDAC1 nuclear expression,and about 19.1％ of them showed more than 50％ nuclear expression. In 6 individuals who underwent tumor relapse with increasing in WHO grade,the immunoreactivity was decreased with tumor progression in 2 cases,remained stable immunoreactivity in 3 cases,and increased in 1 case.In 20 cases who underwent tumor relapse without increasing in WHO grade,HDAC1 immunoreactivity was decreased in 4 cases,remained stable in 4 cases and increased in the rest 12 cases.HDAC1 expression showed no correlations with WHO grade,Ki-67 expression or Nestin expression,and there was no significant association between HDAC1 expression and patients' survival (P ＞ 0.05,respectively).Conclusion Our findings suggest that HDAC1 is strongly expressed in astrocytic tumors and HDAC1 expression is increased during tumor recurrence. Key words: Histone deacetylase 1; Astrocytic tumor
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