Abstract
Our group have previously reported the expression of H1 and H2 histamine receptors in human [1] and experimental m a m m a r y carcinomas [2]. In particular, in the NMUinduced m a m m a r y tumors in rats, histamine behaves as a growth factor [3] and modulates tumor cell growth in vivo and in vitro by acting th rough specific membrane receptors [4]. In the present work, we investigated the expression of histamine H1 and H2 receptors in different cell lines derived f rom h u m a n m a m m a r y carcinomas and epithelial m a m m a r y gland, in order to elucidate a possible role for histamine in the neoplastic t ransformat ion of the gland.
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