Expression Of Hippo-YAP Signaling Pathway in Gynecological Tumors

Abstract

Ovarian cancer, breast cancer and cervical cancer are common female malignant tumors. YAP signal is widely activated in human malignant tumors. Hippo-YAP signal pathway affects the proliferation and development of tumors. However, the transmission mechanism of YAP signal in gynecological malignant tumors is still unclear. The function of YAP in the Hippo signal route is examined in this research, along with its functions upstream, middle, and downstream of the Hippo signal route. In addition, the mRNA expression data of YAP in ovarian serous cystadenocarcinoma and normal ovarian tissue is compared. The expression of YAP in breast invasive carcinoma (BRCA) is observed by IHC, and the YAP intensity of cytoplasm and nucleus is evaluated. Through the relationship between YAP and HPV, to further investigate the mechanism of YAP in cervical cancer, the distribution of YAP1 in cells adhering to the cervical surface was studied. These findings are critical in the treatment of YAP as a potential therapeutic target. Furthermore, understanding the role of YAP in female malignant tumors provide an insight in developing drugs that block the activity of YAP or inhibit the activation of YAP, they can play an anti-tumor role in vivo.