Abstract
The aim of this study was to discuss HIF-1α expression and vasculogenic mimicry (VM) in hepatocellular carcinoma (HCC) and their relationship with the clinical pathological features and clinical significance. Two hundred and seven specimens from patients in The Affiliated Hospital of North Sichuan Medical College who received hepatic cell carcinoma resection were tested by immunohistochemistry and double staining of CD31 and PSA. Then detected the expression of HIF-1α, VM, and analysed the relationship between clinical pathology. The HIF-1α positive rate was 71.01% and its expression was associated with liver cirrhosis, tumor size and TNM stage (P < 0.05). HIF-1α protein expression was positively associated with the VM (γ = 0.1988, P = 0.0041). Hypoxia may be the reason for VM in high invasive HCC, regulating the tumor microenvironment may have great significance in inhibiting invasion and metastasis of HCC.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.