Abstract
The activity of hepatic microsomal cholesterol 7α-hydroxylase was studied in genetically obese and lean Zucker rats. The liver microsomal cholesterol 7α-hydroxylase activity in fatty Zucker rats ( fa fa ) is about 50% to 70% lower than that of the lean (Fa/−) rats of the same sex, when animals were sacrificed at the middle of the dark cycle. When rats were sacrificed at the middle of the light cycle, cholesterol 7α-hydroxylase activity was the same as in the dark cycle in obese rats of both sexes, but was 65% lower in lean rats. However, cholesterol 7α-hydroxylase activity was stimulated by the treatment with cholestyramine in both obese and lean rats. Our results suggested that the diurnal regulation of cholesterol 7α-hydroxylase activity is lost in obese rats but was present under cholestyramine treatment in the genetically obese strain of rats.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
