Abstract
Objective To investigate the expression of heparanase (Hpa) in serum and tissue of patients with papillary thyroid carcinoma (PTC) and its clinical significance. Methods Immunohistochemical method (SP) and enzyme linked immunosorbent assay (ELISA) were used to detect the expression of Hpa protein in serum and tissues of 38 cases of PTC, 37 cases of patients with benign thyroid nodules, and 30 normal controls. Results Expression of Hpa in PTC was higher than that of benign thyroid nodules (P 0.05) . Hpa content in serum of patients with PTC was higher than that of benign thyroid nodules group and the normal control group (P<0.01) . There was no statistically significant difference of the level of serum Hpa between groups with and without lymph node metastasis. Conclusions Detecting tissue and preoperative serum Hpa concentration is valuable for diagnosis of PTC. Hpa detection in tissues can be used to determine whether there was lymph node metastasis in PTC patients, while Hpa detection in preoperative serum can not judge whether there is lymph node metastasis. Key words: Papillary thyroid carcinoma; Benign thyroid nodules; Hpa; Immunohistochemistry; Enzyme-linked immunosorbent assay
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