Abstract
BackgroundHeat shock protein 70, a stress protein, has been implicated in tumor progression. However, its role in nasopharyngeal carcinoma (NPC) progression has not yet been clearly investigated.MethodsImmunohistochemistry (IHC) was employed to examine the expression patterns of Hsp70, human leukocyte antigen –A (HLA-A) in NPC tissue samples.ResultsThe expression of Hsp70 exhibited different spatial patterns among nuclear, membrane and cytoplasm in 507 NPC tumor tissues. Kaplan-Meier survival analysis demonstrated that different Hsp70 expression patterns are correlated with different patient outcomes. High membranal and cytoplasmic levels of Hsp70 predicted good survival of patients. In contrast, high nuclear abundance of Hsp70 correlated with poor survival. Moreover, the membranal and cytoplasmic levels of Hsp70 were positively correlated with levels of the MHC I molecule HLA-A.ConclusionsDifferent Hsp70 expression patterns had distinct predictive values. The different spatial abundance of Hsp70 may imply its important role in NPC development and provide insight for the development of novel therapeutic strategies involving immunotherapy for NPC.
Highlights
Heat shock protein 70, a stress protein, has been implicated in tumor progression
Novel therapies based on molecular targets and neoadjuvant chemotherapy (NAC) followed by RT of nasopharyngeal carcinoma (NPC) were promising for advanced lesions [7,8], though need to be validated in more trials
Correlation between the heat shock protein 70 (Hsp70) abundance and the expression of human leukocyte antigen –A (HLA-A) In light of the involvement of Hsp70 in the antigen presentation process, which human leukocyte antigen (HLA)-A plays important role, we further investigated the correlation between its abundance and HLA-A expression
Summary
Its role in nasopharyngeal carcinoma (NPC) progression has not yet been clearly investigated. Nasopharyngeal carcinoma (NPC) is a leading lethal malignancy with a high prevalence in Southeast Asia, especially in the Guangdong, Guangxi and Hong Kong areas in Southern China [1,2]. The incidence rate of NPC is 25–40 cases per 100,000 person-years in the Cantonese region of Southern China [3]. Most NPC tumor cells are poorly differentiated or undifferentiated and have high tendency to invade adjacent regions and metastasize to neck lymph nodes. Therapeutic strategies have been studied aiming to improve the survival rate for advanced NPC. It is of clinical value to identify factors that allow for an early diagnosis and the prediction of prognosis and to discover novel therapeutic strategies
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