Expression of GPR48 in tissues of prostate cancer and its clinical significance

Abstract

Objective To investigate the expression of G protein-coupled receptor 48 (GPR48) in the tissues of prostate cancer and its clinical significance. Methods The specimens of pathologically-confirmed cancer tissues and adjacent normal tissues fom 42 prostate cancer patients who underwent resection in our hospital between January 2012 and March 2017 were included in the study. The relative mRNA and protein expression of GPR48 were determined by real-time PCR and immunohistochemistry, respectively. The correlation between GPR48 expression and clinicopathological parameters was analyzed. Results The relative expression of GPR48 mRNA in prostate cancer tissues and adjacent normal tissues were 0.534±0.032 and 0.212±0.023, respectively (P 0.05) , and the expression of GPR48 was positively correlated with the preoperative total serum PSA value, TNM staging, and Gleason score (P<0.05) . Conclusion The expression of GPR48 is closely related to the malignant degree of prostate cancer, and it is expected to become a potential biomarker for prostate cancer. Key words: Prostate cancer; GPR48; PSA; Gleason score