Abstract
The distribution of glycine receptor subunit mRNAs in the cochlear nucleus of the adult rat was examined using radioactive in situ hybridization. Expression was compared among six cell types by counting silver grains over somata. Expression of the immature α2 subunit was not above the threshold for detection in any neurons. Levels of expression of mature subunits varied among different cell types. Spherical bushy, small cell cap/shell neurons and fusiform cells had high expression of glycine receptor mRNA for α1, α3 and β subunits. Octopus cells and corn cells had high expression for α3 and β subunits, and only moderate expression for α1 subunit. Granule cells located between the dorsal and ventral cochlear nucleus had moderate expression of α3 and β subunits and no detectable α1 expression. These patterns of expression predict differences in glycinergic pharmacological properties between the cochlear nucleus neurons.
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