Expression of Girdin protein and its correlation with tumor's invasion and metastasis in colorectal carcinoma

Abstract

Objective To investigate the expression of Girdin protein in colorectal carcinoma, and explore its relationship with clinical characteristics and tumor's invasion and metastasis. Methods Eightyfour cases of colorectal carcinoma specimens, 40 cases of colorectal adenoma and 30 cases of tumoradjacent mucosal tissues were collected, and the expression levels of Girdin protein were detected by immumihistochemistry Envision two-step methods. The relationship between Girdin expression and clinicopathological characteristics was analyzed. Results The positive expression rate of Girdin protein in colorectal carcinoma was 42.9%, which was significantly higher than that in tumor- adjacent mucosa, adenoma with low grade inraepithelial neoplasia(LGIN)and adenoma with high grade inraepithelial neoplasia(HGIN)respectively(χ2= 15.752,P 0.05). Follow- up study results showed that the five- year overall survival rate in Girdin negative group(83.3%)was higher than that in Twist positive group(21.7%)significantly(P<0.01). Conclusion Girdin protein expression is up- regulated in colorectal carcinoma and correlated with tumor's invasion and metastasis. Key words: Colorectal neooplasms; Girdin; Neooplasms metasasis