Abstract
Objective To observe the expression and clinical significance of galectin-1 in Chinese laryngeal squamous cell carcinoma patients. Methods Immunohistochemical technique was used to test the galecin-1 protein expression in the 50 laryngeal squamous cell carcinoma patients and Western blot method was used to test the galecin-1 protein expression in the 3 of the patients. SAS 9.4 software was used to analyze the relationship between the galectin-1 protein and the clinical degrees, pathological grades and lymph node metastasis in all the cases. Results In the 50 laryngeal squamous cell carcinoma patients, the positive rate of galectin-1 protein was 74% (37/50). The expression of galectin-1 protein was correlated with the severity of clinical staging, pathological differentiation and lymph node metastasis. Conclusions High expression of galectin protein related with the occurrence and development of head and neck squamous cell carcinomas. Key words: Laryngeal squamous cell carcinoma; Galectin-1; Immunohistochemical technique
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