Abstract
Expression of Foxp3 and Rorc Genes in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation: Impact in the Development of Acute and Chronic Graft-Versus-Host Disease
Highlights
Graft versus host disease (GVHD) is a leading cause of morbidity and mortality following hematopoietic cell transplantation (HCT) [1]
We found statistically significant differences when healthy controls, no GVHD, acute GVHD (aGVHD) and chronic GVHD (cGVHD) where analyzed for Forkhead Box Protein 3 (FOXP3) (p = 0.006) and related orphan receptor (RORC) expression (p = 0.0042) (Figure 1, Kruskal-Wallis test followed by Mann-Whitney test, with Bonferroni posttest)
Our study confirmed the role of T-Helper-17 Cell (Th17) and T Regulatory Cell (Treg) related genes in the pathogenesis of GVHD
Summary
Graft versus host disease (GVHD) is a leading cause of morbidity and mortality following hematopoietic cell transplantation (HCT) [1]. CD4+ T cells play a critical role in mediating GVHD and understanding the Citation: Cabral CMV, Braga WMT, Arantes AM, de Oliveira JSR, Colleoni GWB, et al (2018) Expression of Foxp and Rorc Genes in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation: Impact in the Development of Acute and Chronic Graft-Versus-Host Disease. CD4+ CD25+ FOXP3+ Regulatory T (Treg) cells are key immunoregulatory cell population involved in the maintenance of immune tolerance and have been used to prevent and treat GVHD [4,7]. Tregs in the peripheral blood of human HCT recipients have been reported to be lower in the presence of acute GVHD (aGVHD) [4,12,13]. In chronic GVHD (cGVHD), this correlation between increased Tregs and decreased risk of GVHD has been absent [14,15] or even reversed [16]
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