Abstract
Objective To investigate the relationship between the expression of focal adhesion kinase (FAK) in human epithelial ovarian cancer (EOC) and clinicopathological features. Methods From June 2004 to December 2007, western-blot was used to detect the expression of focal adhesion kinase in 56 epithelial ovarian cancer with different clinical stages and different degrees of differentiation (research group). Research group was furthermore divided into following sub-groups: Lymph node metastasis sub-group (n=37), and non-lymph node metastasis sub-group (n=19); <50-year-old group (n=27) and ≥50-year-old group (n=29); T1, T2 sub-group (n=15) and T3, T4 sub-group (n=41) according to the clinical staging of malignant tumors made by International Federation of Gynecology and Obstetrics (FIGO) in 2000; grade Ⅰ sub-group (n=16), grade Ⅱ sub-group (n=25), and grade Ⅲ sub-group (n=15) according to the principle of pathological classification of malignant tumors; serous sub-group (n=30), mucinous sub-group (n=16), and endometrioid carcinoma sub-group (n=10) by different histological types. Another 22 cases with ovarian benign tumors were included to control group, including 14 cases with serous papillary cystadenoma and 8 cases with mucinous papillary cystadenoma. Informed consent was obtained from all participants. The positive expression rate of focal adhesion kinase between research group and control group was compared. The relationship between expression levels of focal adhesion kinase and clinicopathological characteristics were analyzed by χ2 test and Fisher exact test. Results The positive rate of focal adhesion kinase in research group was 76.9%(43/56) and in control group was 9.1%(2/22) (P 0.05). Conclusion The expression level of focal adhesion kinase in ovarian cancer is higher than that of benign tumors. The positive expression rate of focal adhesion kinase has a close relationship with clinical staging and lymph node metastasis of epithelial ovarian cancer, but it has no relationship with age, pathological grades and histological types of tumors. Key words: epithelial ovarian cancer(EOC); focal adhesion kinase (FAK); metastasis
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