Abstract
To investigate the expression of survivin and its relation with apoptosis in non-small cell lung cancer. Survivin expression was examined in sixty paraffin-embedded NSCLC samples and 16 benign pulmonary disease tissues by immunohistochemistry methods.Apoptosis of NSCLC cells was detected by TUNEL technique. Survivin was expressed in 38 of 60 (63.3%) NSCLC tissues.In contrast, benign pulmonary disease tissues did not express survivin. The expression of survivin protein was closely related to TNM stages (P < 0.05), lymph node involvement (P < 0.05) and cell differentiation (P < 0.01), but not to histological classification, gender and ages (P > 0.05). A correlation coefficient test showed a negative correlation between the AI and survivin expression (r=-0.231,P < 0.05). Apoptosis inhibition caused by abnormal survivin expression may participate in the oncogenesis and progression of NSCLC. The over-expression of survivin suggest the bad prognosis in NSCLC. Survivin gene may be indentified as a potential therapeutic target in NSCLC.
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Schedule a callMore From: Zhongguo fei ai za zhi = Chinese journal of lung cancer
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