Expression of fibroblast growth factor receptor 1 and proliferation cell nuclear antigen in breast cancer tissue

Abstract

Objective To analyze the relationship between the expression level of fibroblast growth factor receptor 1(FGFR1), proliferation cell nuclear antigen(Ki- 67)and clinicopathological features in breast cancer tissue. Methods Clinicopathologic data of 203 patients with breast cancer treated in the First Affiliated Hospital of Zhengzhou University from Apr.to Oct.2014 were analyzed retrospectively.Streptavidin- peroxidase(SP) immunohistochemical techniques were adopted to detect the expression of FGFR1 and Ki- 67. The correlation of FGFR1 and Ki- 67 expression with the clinicopathological features in the breast cancer tissue was analyzed. Results The positive expression rate of FGFR1 in breast cancer tissues was 36.94%(75/203).The expression of FGFR1 was positively related to the lymph nodes status(52.44% vs.26.45%)and histological grade(0 for gradeⅠ, 31.19% for gradeⅡ, and 56.16% for gradeⅢ)(P<0.05).Among the 203 cases, the mean value of Ki- 67 index was 30.54%(0.8% to 97.0%), and correlated with age, lymph nodes status and histological grade(P< 0.05). Logistic regression analysis showed that the histological grade of breast cancer tissues was the main factor impacting the expression of FGFR1 and Ki- 67 (P< 0.05) Conclusion Our results suggested that the expression of FGFR1 and Ki- 67 have a close correlation with lymph nodes status and histological grade.The expression of FGFR1 was positively related to Ki- 67 in breast cancer tissues. Key words: Breast cancer; Fibroblast growth factor receptor 1; Proliferation cell nuclear antigen