Abstract
Various estrogen receptor β exon-deleted variant (ER-β EDV) mRNAs were expressed in human ovary and uterine endometrium. Estrogen receptor β (ER-β) completely or partially deleted exon n is expressed as ER-β EnDV or En′DV, respectively. The mRNAs for ER-β single exon-deleted variant (EDV), ER-β E2DV, E4DV, E5DV and E6DV; for ER-β double exon-deleted variants, ER-β E1′+2DV, E4+5DV and E5+6DV; and for ER-β triple exon-deleted variants, ER-β E2′+3+4DV and E4+5+6DV were detected. In ER-β E2DV, E4+5DV, E5DV and E6DV mRNAs, the new stop codon is made in the exon following the deleted exon(s), and the new proteins may lack the corresponding domains. In ER-β E1′+2DV, E2′+3+4DV, E4DV, E4+5+6DV and E5+6DV mRNAs, the original stop codon is still present, and the new proteins may conserve the new short amino acid sequences surrounding the deleted exons. ER-β E1′+2DV, E2DV, E2′+3+4DV, E4DV, E4+5DV and E4+5+6 are unlikely to work as a transcription factors. On the other hand, ER-β E5DV, E6DV and E5+6DV lack only the ligand-binding domain, and might work as dominant positive or negative factors. Therefore, ER-β E5DV, E6DV and E5+6DV, constitutively expressed in human ovary and uterine endometrium might, in part regulate estrogen responsiveness.
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