Abstract
Objective To investigate the expression of erythropoietin receptor (EPOR) in human gliomas and its relationship with histopathological degree and neovascularization.Methods Immunohistochemistry of the tissue microarray was used to detect the expression of EPOR and CD105 in gliomas.Tissue samples included 152 gliomas of different WHO grades and 20 normal brain tissue specimens.Twenty-one gliomas and 6 normal brain tissue specimens were detected by using real-time fluorescent quantitative polymerase chain reaction (FQ-PCR).Results The expression of EPOR was significantly higher in glioma specimens than in normal brain tissues (x2 =7.7038,P ＜ 0.01),and EPOR expression was positively correlated with the stage of the tumor (rx =0.3151,P ＜ 0.01).CD105 counts of EPOR (艹,(艹)) were greater than those of EPOR(－,+) (P ＜0.05).There was no significant difference in the EPOR mRNA expression in glioma group and normal brain group.Conclusion Tbe expression of EPOR in human glioma exhibits a positive correlation with histopathological degree and neovascularization.There is no up-regulation of EPOR mRNA. Key words: Glioma; Erythropoietin receptors; CD105 ; Tissue arrayer
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