Abstract
Cancer cells may interact with normal host cells, during various steps of the tumor mass formation. This interaction is supposed to modify the biological characteristics of cancer cells and cause the gene's expression. Therefore, we investigated the expression rate of EBV early antigen (EA) and viral capsid antigen (VCA) by means of coculture of nasopharyngeal hybridoma cells and fibroblast cells. The former cells are EBV genome-positive but non-producer cells.We observed an enhancement effect of EBV antigen by coculturing the epithelial cancer cells and mesenchymal fibroblast cells. It was considered that intercellular communication have some influences on the reactivation of EBV genome and production of the viral particles.
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