Expression of epidermal growth factor receptor, carbohydrateantigen 125, and carbohydrateantigen 199 in postoperative non-small cell lung cancer patients with bone metastasis

Abstract

Objective To investigate the expression of epidermal growth factor receptor (EGFR) in the tissue of non-small cell lung cancer (NSCLC), and the expression of carbohydrateantigen 125 (CA125), and carbohydrateantigen 199 (CA199) in postoperative NSCLC patients with bone metastasis and without bone metastasis, and discuss the roles of EGFR, CA125 and CA199 in postoperative NSCLC patients with bone metastasis. Methods Sixteen cases of postoperative NSCLC with bone metastasis served as the experimental group, and 16 cases of postoperative NSCLC without bone metastasis as the control group. The expression of EGFR in the lung cancer, and the serum levels of CA125 and CA199 were determined. Results The strong positive rate of EGFR was 81.2% in the experimental group. The CA125 and CA199 positive rate in the experimental group was 56.3% and 43.8% respectively. Combined detection positive rate was 81.3%. The strong positive rate of EGFR was 6.2% in the control group. The CA125 and CA199 positive rate in the control group was 0. Combined detection positive rate was 0. The serum levels of CA125 and CA199 in the experimental group were (138.05±141.06) Ku/L and (78.06±112.86) U/ml, and those in the control group were (9.94±6.50) Ku/L and (9.40±4.66) U/ml respectively. Conclusion With the high expression of EGFR, combined detection of CA125 and CA199 has certain significance in the early diagnosis of bone metastasis in postoperative NSCLC patients. Key words: Non-small cell lung cancer; Bone metastasis; Epidermal growth factor receptor; Carbohydrateantigen 125; Carbohydrateantigen 199