Abstract
The aim of this study was to assess EGFR and p53 expression in head and neck tumors among Sudanese patients using immunohistochemistry. A retrospective descriptive study was performed on 150 samples from patients diagnosed with HNCs as well as 50 from individuals with benign head and neck tumors. EGFR and p53 expression was assessed using immunohistochemistry (IHC). EGFR was expressed in 126/150 (84%) of HNCS and 6/50 (12%) benign head and neck tumors where as p53 was expressed in 29/150 (19.3%) of HNCs and 2/50 (4%) of benign head and neck tumors, with significance at p values of 0.001 and 0.009 respectively. There is a significant association between EGFR, P53 expression and head and neck cancers among Sudanese patients.
Highlights
Head and neck cancer comprises malignancies arising in the upper respiratory and digestive tracts and is a relatively frequent type of cancer (Parkin et al, 2002)
Epidermal growth factor receptor (EGFR) was expressed in 126 (84.0%) of head and neck cancers (HNCs) and 6 (12.0%) of benign head and neck tumors. the expression of EGFR is significantly associated with head and neck cancers (HNCs) p value≥(0.000) as shown in Table 1, Figure 2
The increased expression of EGFR in Head and neck squamous cell carcinoma (HNSCC) usually linked to the gene amplification and transcriptional activation (Grandis et al, 1996; Chung et al, 2006)
Summary
Head and neck cancer comprises malignancies arising in the upper respiratory and digestive tracts and is a relatively frequent type of cancer (Parkin et al, 2002). The malignant tumors of the head and neck consist of a rather heterogeneous group of neoplasias arising in the epithelium of the upper aerodigestive tract. Head and neck squamous cell carcinoma (HNSCC) is the seventh most commonly diagnosed cancer worldwide (Ferlay, et al, 2010) and is associated with survival rates. In North America and Europe, HNCs accounts for 3-4% of all cancer diagnoses. The aim of this study was to assess EGFR and p53 expression in head and neck tumors among Sudanese patients using immunohistochemistry. Materials and Methods: A retrospective descriptive study was performed on 150 samples from patients diagnosed with HNCs as well as 50 from individuals with benign head and neck tumors. Conclusions: There is a significant association between EGFR, P53 expression and head and neck cancers among Sudanese patients,
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