Abstract
Objective To study the expression of ezrin-radixin-moesin-binding phosphoprotein50 (EBPS0) and β-catenin protein in hepatocelluar carcinoma(HCC) and investigate its clinical significance with the occurrence or development of hepatocellular carcinoma.Methods Immunohistochemical SABC method was used to detect the expression of EBP-50 and β-catenin protein in 48 cases of HCC,16 cases of normal liver tissues.And the relationship between them and clinical pathological characteristics was analyzed.Results The positive expression rate of EBP50 in HCC tissues,normal liver tissues was 39.6％,87.5％,and there were significant differences(P ＜0.05).The expression of EBP50 in HCC tissues was closely related to the tumor size,tumor differentiation degree (P ＜ 0.05).The positive expression rate of β-catenin in HCC tissues,normal liver tissues was 85.4％,12.5％,and there were significant differences(P ＜ 0.05).The expression of β-catenin in HCC tissues was closely related to HBsAg,the tumor size and tumor differentiation degree (P ＜ 0.05).Conclusions EBP50 and β-catenin may play an important role in the processe of the occurrence and development of hepatocellular carcinoma,and are expected to be the important indicator for the diagnosis of HCC. Key words: Hepatocellular carcinoma; EBP50 ; β-catenin; Immunohistochemical
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