Abstract
Objective To investigate the expression and clinical significance of DJ-1 protein in the endometrial carcinoma and delineate its functional roles in endometrial carcinoma progression. Methods Expression of DJ-1 was examined with immunohistochemical staining of 69 paraffin-embedded endometrial carcinoma samples who underwent surgery at Hunan province Tumor Hospital. Kaplan-Meier analysis was performed to describe the survival curve. Univariate and multivariate analyses were performed with COX proportional hazard model. Results ⑴ The expression of DJ-1 protein in endometrial carcinoma was significantly higher than that in normal endometrial tissues (P 0.05). Conclusions The high expression of DJ-1 protein in endometrial carcinoma samples demonstrated a significantly positive correlation with the pathological grade, FIGO stage, depth of myometrial invasion, and lymph node metastasis. However, DJ-1 is not enough to be independent prognostic factor for overall survival time. Key words: Endometrial neoplasms/ME; Oncogene proteins/ME; Prognosis
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