Expression of decorin in cholangiocarcinoma and clinical implication

Abstract

Objective To investigate the clinical implication of the decorin expression in cholangiocarcinoma.Methods The decorin expression levels were detected by immunohistochemistry in 44 cases of cholangiocarcinoma and 40 cases of normal bile duct tissues.The relationship between the decorin expression level with sex,age,tumor cell differentiation and lymph node metastasis of patients with cholangiocarcinoma was analyzede.Results Decorin expression was down-regulated in human cholangiocarcinomas cancer tissues.Decorin protein was positive in tumor interstitial tissues and the staining was weaker in cholangiocarcinoma tissues than the adjacent noncancerous tissues.The positive expression rate of decorin in human cholangiocarcinomas cancer tissues and the adjacent normal tissues was 40.91％ and 100.00％,respectively (P ＜ 0.01).The expression of decorin in middle-hight differentiation tumor group (57.14％) was significantly higher than in regional lymph node metastasis group (26.09％,P ＜ 0.05).The expression of decorin was not associated with sex,age and tumor cell differentiation of patients with cholangiocarcinoma.Conclusion The expression of decrorin appears to be tumor specificity to some extent in cholangiocarcinoma. Key words: Cholangiocarcinoma; Decorin ; Expression