Abstract
Cytoskeleton in Eukaryotic cell is very important for cell to keep the exact shape and supports the plasma membrane and give the mechanical support to cell. Actin is a type of cytoskeleton that is involved in several functions. Actin filaments are made up of indistinguishable actin binding proteins which is set in a lengthy curved chain which performs important function of body. Expresion of some actin binding proteins are regulated during carcinogenesis and metastasis, these proteins include Arp2/3 (Actin related protein 2 and 3 complex), fascin and the tropomyosin’s, WASP/WAVE (Wiskott-Aldrich syndrome protein/WASP and Verprolin homologous protein) complexes. The expansion of cancer cells from the primary tumor to other tissues and the organs is called metastasis. The connection amongst the hyperactivated signaling pathways plays a very important role in the development of metastatic. GPCRs (G Protein Coupled Receptors) through β-arrs (β-arrestins) act as a intracellular signaling particles. In tumor cells the increased and decreased expression of these actin binding proteins are involved in progression of different types of cancer and metastasis.
 For further insight we have to understand what is actin and the function of actin binding proteins.
Highlights
Cytoskeleton in Eukaryotic cell is very significant for the cell to keep the overall shape and give the mechanical support to cell to perform different functions like movement, division and make available the pathways for vehicles to transport [1].The cytoskeleton is made up of different filamentous protein basically it is divided into 3 major classes which have different sizes and composition of protein
Earlier there are some actin binding proteins whose expression is regulated during carcinogenesis, these proteins include Arp2/3 which is known as Actin related protein 2 and 3 complex, fascin and the tropomyosin’s, WASP/WASP-family verprolinhomologous protein (WAVE) which is known as Wiskott-Aldrich syndrome protein/WASP and Verprolin homologous protein complexes
From many years the role of actin binding protein in carcinogenesis have been studied but there are some reservations of understandings in what way they are involved and their biological significances
Summary
Cytoskeleton in Eukaryotic cell is very significant for the cell to keep the overall shape and give the mechanical support to cell to perform different functions like movement, division and make available the pathways for vehicles to transport [1].The cytoskeleton is made up of different filamentous protein basically it is divided into 3 major classes which have different sizes and composition of protein. The 3 classes include microtubules which is the largest type filament with a diameter of 25 nm, it is used for the transportation within the cell and the is intermediate filaments made up of fibrous proteins and have a diameter of 8-10 nm and it performs the basic function which is forming a network that grips the different organelles and nucleus in one place, and it resides in between the microtubules and microfilaments, which is the third filament protein and the smallest one with the diameter of 6nm and made up of a protein called actin which is double helix and are made up of actin monomer [2].The Actin protein is very important in the motility of muscle cells and other cells.
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