Abstract
Objective: Adenosquamous carcinoma is an exceptionally uncommon malignant tumour with the histological features of both adenocarcinoma and squamous cell carcinoma. This study investigated the histogenetic aspects of adenosquamous carcinoma with the aim of assisting the differential diagnosis.Patients and Methods: Immunohistochemical methods using monoclonal antibodies against cytokeratin 10/13, 14, 18, and 19 were used to clarify the antigenic profile of adenosquamous carcinoma.Results: The distribution of cytokeratin 10/13 was localised in the squamous components of adenosquamous carcinoma and squamous cell carcinoma, except for the basal layer. The reaction for cytokeratin 14 was distinctly positive in the basal cells. The positive reaction for cytokeratin 18 was mainly observed in the luminal columnar cells of adenosquamous carcinoma, whereas it was negative in oral squamous cell carcinoma. No reaction for cytokeratin 19 was observed in either adenosquamous carcinoma or squamous cell carcinoma.Conclusion: These findings indicate that the immunoprofile of cytokeratins might make them useful markers for discriminating between adenosquamous carcinoma and squamous cell carcinoma in the diagnosis of oral tumours.
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