Expression of cystic fibrosis transmembrane conductance regulator in oral squamous cell carcinoma and its correlation with tumour angiogenesis

Abstract

Background and Objectives: Angiogenesis is a crucial step in the growth, invasion, and metastasis of a tumour. Transmembrane transport of excessive Cl– and K+ plays a crucial role in apoptosis of cells. Cystic fibrosis transmembrane conductance regulator (CFTR) is an important type of Cl– channels. The objective of this study was to investigate whether the expression of CFTR in oral squamous cell carcinoma (OSCC) is correlated with angiogenesis, so as to provide the experimental foundation for therapy of OSCC.