Abstract
Objectives: The aim of this study was to elucidate the role of arachidonic acid metabolism in the growth of laryngeal granuloma via the cyclooxygenase pathway. Methods: We examined expression of cyclooxygenase-1 and -2 (COX-1 and COX-2) in laryngeal granuloma in 6 patients. For controls, normal vocal fold in 6 cases were examined in the same method that were obtained from the totally resected larynx because of noninflammatory diseases. Results: Expression of COX2 was observed in the epithelial cells of laryngeal granuloma, however, less expression of COX2 in epithelial cells of the vocal fold. Conclusion: Arachidonic acid metabolism may promote the growth of laryngeal granuloma. This evidence suggests the effectiveness of steroids or NSAIDs in the treatment of laryngeal granuloma.
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