Abstract
Objectives: The aim of this study was to elucidate the role of arachidonic acid metabolism in the growth of laryngeal granuloma via the cyclooxygenase pathway. Methods: We examined expression of cyclooxygenase-1 and -2 (COX-1 and COX-2) in laryngeal granuloma in 6 patients. For controls, normal vocal fold in 6 cases were examined in the same method that were obtained from the totally resected larynx because of noninflammatory diseases. Results: Expression of COX2 was observed in the epithelial cells of laryngeal granuloma, however, less expression of COX2 in epithelial cells of the vocal fold. Conclusion: Arachidonic acid metabolism may promote the growth of laryngeal granuloma. This evidence suggests the effectiveness of steroids or NSAIDs in the treatment of laryngeal granuloma.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.