Abstract
The aim of this study was to evaluate cyclooxygenase-2 (COX-2) immunoreactivity in colorectal adenocarcinomas and to find correlations with different pathological features. This study included 35 cases of colorectal carcinoma for which surgical colectomy specimens were collected. Immunohistochemical staining of COX-2 (cyclooxygenase-2) is done by using the Streptavidin-biotin technique. This work reveals that COX-2 is positive in most cases of colorectal carcinoma and negative in normal colon tissue with statistically non significant relations between COX-2 immunostaining and different pathological features. Our data suggest overexpression of COX-2 protein in colorectal carcinoma in contrast to normal mucosa, with a possible role in cell proliferation in carcinogenesis.
Highlights
Colorectal cancer (CRC) is a major cause of mortality and morbidity worldwide, being the third most common malignant tumors in the world (Jemal et al, 2011), (Sameer et al, 2010)
This work reveals that COX-2 is positive in most cases of colorectal carcinoma and negative in normal colon tissue with statistically non significant relations between COX-2 immunostaining and different pathological features
Our data suggest over expression of COX-2 protein in colorectal carcinoma in contrast to normal mucosa, with a possible role in cell proliferation in carcinogenesis
Summary
Colorectal cancer (CRC) is a major cause of mortality and morbidity worldwide, being the third most common malignant tumors in the world (Jemal et al, 2011), (Sameer et al, 2010). COX2 is closely involved in the carcinogenesis process and is over expressed in adenocarcinoma in contrast with non-cancerous mucosal regions in colon cancers and gastric cancers (Tsujii et al, 1998). It is involved in a variety of important cellular functions, including cell growth and differentiation, cancer cell motility and invasion, angiogenesis and immune functions (Dempke et al, 2001). Results: This work reveals that COX-2 is positive in most cases of colorectal carcinoma and negative in normal colon tissue with statistically non significant relations between COX-2 immunostaining and different pathological features. Conclusions: Our data suggest over expression of COX-2 protein in colorectal carcinoma in contrast to normal mucosa, with a possible role in cell proliferation in carcinogenesis.
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