Abstract
Expression of cyclin d1 in normal, hyperplastic and neoplastic endometrium
Highlights
Endometrial carcinoma is one of the most common malignancies of female genital tract.[1] accounting for 7 % of all invasive cancers in women
The 7 patients diagnosed with complex hyperplasia without atypia had an age range of 38-65 years with mean age of 47.14±10.35years and a maximum number of 3 cases (30%) were in the age group of 36-40 years
The 4 patients diagnosed with complex hyperplasia with atypia had an age range of 3173 years with mean age of 50.50±19.07years
Summary
Endometrial carcinoma is one of the most common malignancies of female genital tract.[1] accounting for 7 % of all invasive cancers in women. Type 1 carcinoma / Endometrioid carcinoma is the most common type accounting for approximately 80 % of cases. It typically arises in the setting of endometrial hyperplasia and is seen in 55-65 years age group. Aim: The present study was undertaken to examine the expression profile of Cyclin D1 in normal, hyperplastic and neoplastic endometrium and to evaluate the possibility of its role in the genesis of endometrial neoplastic and preneoplastic lesions. Materials and Methods: We evaluated and compared the expression profile of Cyclin D1 in 50 endometrial samplings that were diagnosed as simple hyperplasia without atypia (n=12), complex hyperplasia without atypia (n=7), complex hyperplasia with atypia (n=4), endometrial carcinoma (n=7) and proliferative (n=10) and secretory (n=10) endometrium. Results: An increasing gradient of Cyclin D1 expression was noted in endometrial glands from normal endometrium to hyperplasia to carcinoma Conclusion: Cyclin D1 overexpression is an early event in endometrial carcinogenesis
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