Expression of CXC chemokine receptor 4 in clear cell renal cell carcinoma

Abstract

Objective To investigate the expression of CXC chemokine receptor 4(CXCR4)in clear cell renal cell carcinoma(ccRCC) and its relationship with the clinical pathological parameters of ccRCC. Methods The expression of CXCR4 was detected by immuno-histochemistry method in 63 cases of ccRCCs, 20 cases of para-carcinoma tissues and 20 cases of normal renal tissues. The correlation between expression level of CXCR4 and clinical pathological parameters of ccRCC patients were analyzed, and the clinical significance of its expression in ccRCC was evaluated. Results The positive expression rate of CXCR4(49.2%) in ccRCCs was significantly higher than that in para-carcinoma tissues (15%) and normal renal tissue (10%), and the difference was statistically significant (P<0.05). The expression level of CXCR4 and the clinical stage and pathological grade of ccRCC were correlated (P<0.05), and was associated with lymph node transfer (P<0.05). The CXCR4 negative group overall survival rate[55.2%(16/29)] and the average survival time(46 months) was significantly better than the positive group[38.5%(10/26), 32 months; P<0.05]. Conclusions The expression level of CXCR4 in ccRCC is correlated with the clinicopathological parameters and prognosis. CXCR4 is expected to be an important marker for diagnosis and prognosis evaluation of renal cell carcinoma. Key words: Carcinoma, renal cell; CXC chemokine receptor 4(CXCR4); Diagnosis; Prognosis