Abstract
Objective: Although connexins are thought to provide normally functioning gap junctions via a tumor suppressor gene, new studies point to an abnormal increase of connexins in various carcinomas and sarcomas. Therefore it was aimed to investigate the expression of connexin 43 (Cx43) and connexin 32 (Cx32) in adenomatous and hyperplastic polyps. Materials and Methods: This retrospective study included 32 cases with adenomatous polyps and 42 cases with hyperplastic polyps, between 2014 and 2015. The samples were stained with immunohistochemical staining method with Cx43 and Cx32 and evaluated. Results: In our study, we observed that Cx43 and Cx32 staining increased in hyperplastic polyps compared to adenomatous polyps (p=0.039, p=0.048 respectively). Statistically, there were no significant correlations between age, sex, location, and diameter with staining pattern.Conclusion: Loss of Cx43 and Cx32 staining in adenomatous polyps was noted and thought to be related to dysplasia.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
