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Abstract
Expression of Concern: Synthesized multiple antigenic polypeptide vaccine based on B-cell epitopes of human heparanase could elicit a potent antimetastatic effect on human hepatocellular carcinoma in vivo.
Highlights
Evaluation of the replicate images provided for panel 3e, representing the high dosage antibody (HDA) treatment group, found that one replicate contained regions of similarity when compared with the image published as panel 3a, reported to be from an animal in the low dosage antibody (LDA) treatment group
Panels 3b and 3e are reported to represent samples from the same treatment group immunostained for VEGF and bFGF, respectively, which the authors stated were generated using adjacent slices made by serial section in the same paraffin-embedded hepatoma
Editorial follow up on the concerns noted that the appearance of the VEGF staining and the bFGF staining shown in the panels 3b and 3e is highly similar
Summary
Evaluation of the replicate images provided for panel 3e, representing the HDA treatment group, found that one replicate contained regions of similarity when compared with the image published as panel 3a, reported to be from an animal in the low dosage antibody (LDA) treatment group.
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