Abstract
Expression of Concern: Reduction in ATP Levels Triggers Immunoproteasome Activation by the 11S (PA28) Regulator during Early Antiviral Response Mediated by IFNβ in Mouse Pancreatic β-Cells.
Highlights
There appears to be vertical discontinuity between lanes 1 and 2 in the β5i panel
Incorrect image data were included in the IgG control (“ctr IgG”) lanes of the α1–7 and β5C panels in published Fig 3C
The author commented that they have not observed the α1–7 antibodies to cross-react with β5 or β5i
Summary
Concerns have been raised about Figs 2 and 3 of this article [1]. Specifically: • In Fig 2B, there appears to be vertical discontinuity between lanes 1 and 2 in the β5i panel. • In Fig 3A, similarities were noted between areas in lanes 8–14 and lanes 15–19 of the α1–7 (IFNβ, 24h) blot, and between areas in lanes 9–13 and areas in lanes 14–17 of the α1–7 (no IFN, 24h) blot.
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