Expression of Concern: Antivirus effectiveness of ivermectin on dengue virus type 2 in Aedes albopictus.

doi:10.1371/journal.pntd.0010117

Abstract

Highlights

After this article [1] was published, a concern was raised that for each experimental treatment, the triplicate data reported in Table 1 align quite closely with the group average, with low deviation and no outliers
The corresponding author commented that per [2–5] DENV-2 virus nucleic acid will be present for a long time after death, but this cannot be considered as the degradation rate of nucleic acid in live mosquitoes as used in [1] because in living organisms active enzymes metabolize viral nucleic acid [6–9]
In the post-publication assessment, it was raised that detection of viral RNA is not sufficient to demonstrate whether actual virus is present

Summary

Introduction

After this article [1] was published, a concern was raised that for each experimental treatment (group), the triplicate data reported in Table 1 align quite closely with the group average, with low deviation and no outliers. The authors provided PCR data (S1 File) and analysis results (S2 File) to support Table 1.

Results

Conclusion