Expression of Concern: 24-Hour Rhythms of DNA Methylation and Their Relation with Rhythms of RNA Expression in the Human Dorsolateral Prefrontal Cortex.

doi:10.1371/journal.pgen.1009470

Abstract

Highlights

Following publication of this article [1], concerns were raised regarding the methodology used for the reported analyses and whether the conclusions are fully supported
The Results and Materials and Methods sections incorrectly state, “we performed a series of analyses comparing the observed data to 10,000 permuted null datasets generated by randomly shuffling the times of death in our data while preserving the correlation between DNA methylation sites.”
The authors have clarified that the analyses permuted time of death within each block of 500 contiguous CpG; the permutation is independent across the blocks, preserving local within block correlations

Summary

Introduction

Following publication of this article [1], concerns were raised regarding the methodology used for the reported analyses and whether the conclusions are fully supported. The article included a reporting error pertaining to methods used for the analyses reported in Fig 2A,B of [1].

Results

Conclusion