Abstract
Background Left ventricular hypertrophy (LVH) is a common presentation among hypertensive patients. Micro-RNAs (miRNAs) have been proven to show reproducible dysregulations in hypertrophied cardiac tissues. Three miRNAs, miR-133, miR-155, and miR-195 were used in the study to elucidate the miRNA expression anomaly in heart diseases. MiR-133 and miR-195 have been reported as two highly expressed miRNAs in normal mouse heart tissue. The aim of this study is to observe the relationship of the levels of circulating miR-133, miR-155 and miR-195, with the phenotype of cardiac hypertrophy among LVH patients and normal controls.
Highlights
Left ventricular hypertrophy (LVH) is a common presentation among hypertensive patients
The delta CT means of miR-133, miR-155 and miR-195 were 17.427, 13.343, and 9.406, respectively for the control group
The delta CT means of miR-133, miR-155 and miR-195 for the patient group were 18.078, 13.8427, and 10.2295, respectively
Summary
Left ventricular hypertrophy (LVH) is a common presentation among hypertensive patients. Micro-RNAs (miRNAs) have been proven to show reproducible dysregulations in hypertrophied cardiac tissues. Three miRNAs, miR-133, miR-155, and miR-195 were used in the study to elucidate the miRNA expression anomaly in heart diseases. MiR-133 and miR-195 have been reported as two highly expressed miRNAs in normal mouse heart tissue. The aim of this study is to observe the relationship of the levels of circulating miR-133, miR-155 and miR-195, with the phenotype of cardiac hypertrophy among LVH patients and normal controls
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