Abstract
BackgroundB7 Costimulatory signal is essential to trigger T-cell activation upon the recognition of tumor antigens. This study examined the expression of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules along with HLA-DR and the presence of infiltrating lymphocytes and dendritic cells to assess their significance in patients with nasopharyngeal carcinoma (NPC).MethodsExpression of CD80, CD86, HLA-DR, S-100 protein and the presence of infiltrating lymphocytes and follicular dendritic reticulum cells were immunohistochemically examined on the paraffin-embedded tissue blocks from newly diagnosed NPC patients (n = 50). The results were correlated with clinical outcome of patients.ResultsCD80 and CD86 were each expressed in 10 of 50 cases in which they co-expressed in 9 cases. Univariate analysis revealed that patients with CD80/CD86 expression had significantly better overall survival than those without it (P = 0.017), but after adjustment for stage, nodal status, and treatment, the expression of CD80/CD86 did not significantly correlate with overall survival. Expression of HLA-DR and the presence of infiltrating lymphocytes and dendritic cells did not appear to have impact on the survival of patients.ConclusionExpression of CD80 and CD86 costimulatory molecules appears to be a marker of better survival in patient with NPC.
Highlights
B7 Costimulatory signal is essential to trigger T-cell activation upon the recognition of tumor antigens
BMC Cancer 2007, 7:88 http://www.biomedcentral.com/1471-2407/7/88. This costimulatory pathway involves the interaction of two distinct B7 molecules, B7-1 (CD80) and B7-2 (CD86), which are transmembrane glycoprotein members of the Ig superfamily [5,6,7] expressed on antigen-presenting cells with their T cell counter receptors CD28 and CTLA-4 [8]
The Kaplan-Meier survival curves of the 50 nasopharyngeal carcinoma (NPC) patients were plotted into 2 groups according to immunostaining results with either CD80/CD86 positive or negative (Figure 2)
Summary
B7 Costimulatory signal is essential to trigger T-cell activation upon the recognition of tumor antigens. This study examined the expression of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules along with HLA-DR and the presence of infiltrating lymphocytes and dendritic cells to assess their significance in patients with nasopharyngeal carcinoma (NPC). Identification of a pathobiological correlate of clinical behavior of NPC represents a challenge. The development of such a test may improve the outcome of treatment as high-risk patients could benefit from early intervention and aggressive treatment. This costimulatory pathway involves the interaction of two distinct B7 molecules, B7-1 (CD80) and B7-2 (CD86), which are transmembrane glycoprotein members of the Ig superfamily [5,6,7] expressed on antigen-presenting cells with their T cell counter receptors CD28 and CTLA-4 [8]. Experimental evidence has confirmed the expression of B7 costimulatory molecules in tumor cells of NPC [10,11], it is interesting to determine whether B7 costimulatory molecules are factors influencing the survival outcome of patients
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