Abstract
It has been shown that caveolin-1 plays a potential role as a diagnostic and prognostic biomarker in various cancer types. The aim of the present study was to clarify whether caveolin-1 expressed in the breast cancer stroma could be aprognostic factor for breast cancer patients. We searched the PubMed, ScienceDirect and Web of Science databases for published literature investigating associations between stromal caveolin-1 expression and survival outcome in breast cancer patients. With respect to survival outcomes, the pooled hazard ratios (HRs) of caveolin-1 and the 95% confidence intervals (CI) were calculated. Our meta-analysis identified atotal of 10studies involving 2072 cases. Further investigation demonstrated that a lack of caveolin-1 expression in the breast cancer stroma is ahazard for overall survival (OS) (HR= 2.33, 95% CI: 1.57-3.46) and disease-free/progression-free survival (DFS/PFS) (HR= 3.05, 95% CI: 2.26-4.12) in breast cancer patients. Moreover, lack of caveolin-1 expression in the cancer-associated fibroblasts was asignificant predictor of DFS/PFS (HR= 2.79, 95% CI: 1.75-4.46). Our results indicated that lack of expression of caveolin-1 in the breast cancer stroma is associated with a poor prognosis.
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