Expression of calcium binding protein S100 A7 (psoriasin) in laryngeal carcinoma

Rogério Costa Tiveron,Luiz Carlos Conti De Freitas,David L Figueiredo,Luciano N Serafini,Rui Celso Martins Mamede,Marco A Zago

doi:10.1590/s1808-86942012000400012

Rogério Costa Tiveron, Luiz Carlos Conti De Freitas + Show 4 more

Open Access

https://doi.org/10.1590/s1808-86942012000400012

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Abstract

AbstractMany studies have reported increased expression of S100 A7 (psoriasin) in neoplastic lesions. Among them are studies on breast carcinoma, bladder squamous cell carcinoma, skin tumors and oral cavity squamous cell carcinoma. The expression of S100 A7 has not been described for laryngeal cancer.Objective: This study aims to identify the expression of the calcium-binding protein S100 A7 and its correlation with squamous cell carcinomas of the larynx.Material and Methods: Specimens from 63 patients were submitted to immunohistochemistry testing with antibody S100 A7. Results were classified and compared.Results: The group with highly differentiated tumors had the highest treatment failure scores. Moderately differentiated tumors had higher treatment failure scores than poorly differentiated tumors. Higher scores were predominantly seen on stages I and II in moderately differentiated tumors, whereas score distribution was more homogeneous in advanced stage disease (III and IV). Regarding failure in treatment, the group scoring zero (3/4 complications: 75%) differed significantly from the remaining groups (13/59: 22%).Conclusions: S100 A7 marker was expressed in 93.7% of laryngeal cancer cases, with higher positive correlation rates in more differentiated tumors and significantly lower rates of treatment failure. Scores had no impact on survival rates.

Highlights

Despite the multiple advances in the diagnosis and treatment of laryngeal tumors, the survival rate of affected patients has increased little over the last 30 years
Higher scores were predominantly seen on stages I and II in moderately differentiated tumors, whereas score distribution was more homogeneous in advanced stage disease (III and IV)
S100 A7 marker was expressed in 93.7% of laryngeal cancer cases, with higher positive correlation rates in more differentiated tumors and significantly lower rates of treatment failure

Summary

Introduction

Despite the multiple advances in the diagnosis and treatment of laryngeal tumors, the survival rate of affected patients has increased little over the last 30 years. This is believed to be due to the heterogeneous course of the disease, and it is of fundamental importance to identify the most aggressive ones in order to improve their cure rate by applying a specific treatment. The study of the psoriasin protein is still in an early stage[2]; its presence in urine suggests that it is a noninvasive marker capable of identifying cases of cancer and, according to Skliris et al.[3], by being regulated by the activity of the estrogen receptor, this gene may represent a guide for target therapy. Among them are studies of ductal carcinoma of the breast, spinocellular carcinoma of the bladder, skin tumors and spinocellular carcinoma of the oral cavity[4,5]

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