Abstract
The c-Met protein, known as the hepatocyte growth factor (HGF) receptor, is a transmembrane 190 kDa heterodimer with tyrosine kinase activity, encoded by the c-met oncogene. The HGF/c-Met signalling pathway has been shown to demonstrate various cellular responses, including mitogenic, proliferative, morphogenic and angiogenic activities. Although HGF and c-Met are known to be expressed in a variety of organs and play important roles in signal transduction, studies of its expression correlated with clinico-pathological parameters in breast cancer are rare.
Highlights
Prognostic and predictive factors play important roles in profiling predicts clinical outcome of breast cancer
Genetic tests derived from gene expression profiling studies are likely to become useful as prognostic and predictive tests to guide clinical decision making in the treatment of primary breast cancer
The 76-gene profile was strongly predictive of those patients who will develop a distant metastasis within 5 years or will remain recurrence free during that period and in multivariate analysis when corrected for traditional prognostic factors including grade (HR 5.55; P < 0.00003)
Summary
Prognostic and predictive factors play important roles in profiling predicts clinical outcome of breast cancer. Results Between August 1993 and July 1999, 885 patients with primary breast cancer and four or more tumor-positive lymph nodes were randomized in 10 Dutch centers in a study of high-dose chemotherapy. We conducted a phase II trial to define the safety, the efficacy, the pathological response rate and survival associated with four cycles DXR–GMZ administered every 3 weeks followed by surgery, four cycles of FAC50 as a primary therapy in MBC. Method Fifty-four patients with invasive breast cancer treated in 2004 underwent axillary ultrasound and cytological puncture with fine needle of suspicious nodes before surgery Suspicious nodes were those with at least one of the following signs: long-to-short axis ratio less than 1.5, absence of hilius and cortical disruption. BrdU and MTT exhibited inhibition of DNA synthesis and metabolic activity of treated MBC cells compared with untreated controls
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