Abstract
The maf oncogene (v- maf) was initially identified in an avian oncogenic retrovirus, AS42, which induces musculoaponeurotic fibrosarcoma in vivo and transforms chicken embryo fibroblasts in vitro. Genes of the maf family have important roles in embryonic development and cellular differentiation. Both genes are expressed in a wide variety of tissues including spleen, kidney, lens and liver. The present study was performed to analyze expression of c- maf-1 and mafB genes in skin of embryonic stages from 15 days onwards using in situ hybridization. Expression of c- maf mRNA was first detected on embryonic day (ED) 16 in the nuclei of cells in the basal layer in developing epidermis. On ED 19, high expression was detected in the nucleus of basal keratinocytes and developing hair germs. On postnatal day (PD) 3, expression of c- maf had disappeared in epidermis and hair follicles. MafB showed similar expression patterns as c- maf. Our findings indicate that c- maf and mafB are involved in embryonic development of epidermis and hair follicles.
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