Abstract
To determine the biological behaviour of common odontogenic cystic lesions by analysing and comparing bcl-2 expression amongst them. Our study covered 90 formalin fixed paraffin embedded tissue samples: 26 primary cases each of radicular cysts (RC), dentigerous cysts (DC) and odontogenic keratocysts (OKC) and 12 of recurrent OKCs. Bcl-2 expression was analysed immunohistochemically and data analysis was accomplished using SPSS version 17.0. Means were taken for age while for gender and site of the lesions frequencies and percentages were determined. The Chi-square test was applied to evaluate any statistically significant difference of bcl-2 expression in these lesions and p value of ≤0.05 was taken as significant. All the recurrent OKCs showed a strong positivity for bcl-2 that was absent in all of its primary cases (p value<0.05). Although variation in expression of bcl-2 was not found to be statistically significant between RC and DC, however, it became significant when all primary cases of these common odontogenic lesions were compared. Recurrent OKC showed comparatively a more aggressive behaviour than their primary counterparts and also from RC and DC. Bcl-2 proved to be a valuable adjunct in determining aggressive biological behaviour of odontogenic lesions.
Highlights
Odontogenic cysts (OC) are one of the most frequently reported pathologies; characterized by pathological fluid filled cavities and lined by odontogenic epithelium
Expression of Bcl-2 in Primary and Recurrent odontogenic keratocysts (OKC) in Comparison with Other Odontogenic Lesions bcl-2 (Photomicrograph 1) that proved statistically significant when compared with primary OKCs
Limited work has been done on bcl-2 expression in OKC and other odontogenic cysts and most of it is confined to primary lesions
Summary
Odontogenic cysts (OC) are one of the most frequently reported pathologies; characterized by pathological fluid filled cavities and lined by odontogenic epithelium. Studies have been conducted in the past to detect its role in tumourigenesis, a few to evaluate its role in determining the biological behaviour of odontogenic cysts (Zyada et al, 2009; Kelly and Strasser, 2011; Jaafar et al, 2012). This no doubt has done some part of work on the primary odontogenic cysts, still data regarding its expression in recurrent OC and the cysts showing dysplastic changes or malignant transformation of their epithelial lining is lacking. The objective was to analyse expression of the bcl-2 oncoprotein in primary and recurrent OKC and its comparison with RC and DC in our set up
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