Expression of basic fibroblast growth factor(bFGF) in healing human gastric ulcer

Abstract

AIM:To investigate changes of basic fibroblast growth factor (bFGF) in the healing of human gastric ulcer. METHODS:The expression of basic fibroblast growth factor (bFGF) in human gastric mucosa: normal (20 cases), active stage of gastric ulcer (24 cases), healing stage of gastric ulcer (26 cases) and scarring stage of gastric ulcer (20 cases) was detected by immunohistochemical methods and computerized image analysis. RESULTS:The expression intensity of bFGF was different among normal gastric mucosa and mucosa at different stages of gastric ulcer. The expression in normal gastric mucosa was weakly positive, at the active stage of gastric ulcer was positive, at the healing stage and scarring stage was strongly positive. The positive signal of bFGF was localized in granulation tissues, extracellular matrix (ECM), fibroblasts and endothelial cells. There were significant differences in average integral optic density and area density among different stages of gastric ulcer and normal gastric mucosa (0.247±0.042, 0.321±0.096, 0.296±0.048 vs 0.125±0.062, P<0.05; 0.131±0.024, 0.165±0.031, 0.162±0.028 vs 0.081±0.008, P <0.05) They were significantly higher at the healing stage and scarring stage than that at the active stage in average integral optic density and area density ( 0.321±0.096, 0.296±0.048 vs 0.247±0.042, P <0.05; 0.165±0.031, 0.162±0.028 vs 0.131±0.024, P<0.05). CONCLUSION:The changes of bFGF were closely related to the healing of human gastric ulcer, and rational use of bFGF can promote the healing of gastric ulcer.