Abstract
PurposeTo investigate the expression of Aurora Kinase A and B in patients with chondrosarcoma and consider it as a prognostic marker and molecular target of therapy.MethodsTo evaluate the relationship of the Aurora Kinase A and B and the clinical pathological parameters and prognosis of chondrosarcoma. 72 case chondrosarcoma and 42 case chondroma were performed immunohistochemistry on the tissue microarray paraffin sections. The survival time of patients was followed-up.ResultsThe expression of Aurora Kinase A and B in chondrosarcoma was significantly higher than that in chondroma (p<0.01). There were differences about the expression of Aurora Kinase A and B in chondrosarcoma between the recurrence group and the non-recurrence group, metastatic group and non-metastatic group (p<0.05), but not age and gender (p>0.05). The expression of Aurora Kinase A and B were significantly lower in group low grade conventional chondrosarcoma than that in groups medium and high grade conventional chondrosarcoma (p<0.01). The expression of Aurora Kinase A and B in chondrosarcoma showed a positive correlation (p<0.01). According to the Kaplan Meier analysis and multivariate Cox regression analysis, the survival rate was significantly different between the patients with positive Aurora Kinase A and the patients with negative expression (p<0.05) and Aurora Kinase A expression was an independent risk marker of survival(HR=11.263, 95%CI: 2.317–54.748, P=0.003).ConclusionBoth the Aurora Kinase A and B might involve in the oncogenic, invasive and metastatic process of chondrosarcoma; however, the mechanism is still unclear. The Aurora Kinase A and B could be used as a new prognostic marker and molecular therapeutic target for chondrosarcoma.Virtual SlideThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9101494267377096.
Highlights
Chondrosarcoma is the second most common malignant bone tumors following the osteosarcoma in China [1], in which the tumor cells can generate a lot of bone matrix
Our results showed that the expression of Aurora Kinase A was very low in chondroma tissues, while it was strongly expressed in chondrosarcoma; which indicated that Aurora Kinase A played an important role in the initial and developmental stage of the chondrosarcoma
The results showed that the expression of Aurora Kinase A was significant different between the recurrence group and the non-recurrence group, the metastatic group and non-metastatic group, suggesting that the high expression of Aurora kinase A is associated with oncogenesis and the grade of the malignancy and differentiation of chondrosarcoma
Summary
Chondrosarcoma is the second most common malignant bone tumors following the osteosarcoma in China [1], in which the tumor cells can generate a lot of bone matrix. The Aurora Kinase family consists of 3 members in mammal: Aurora Kinase A, B and C. In recent study, it showed that tumorigenesis appeared by transfection of the Aurora Kinase A gene into 3T3 cells in nude mouse [2], and the Aurora Kinase A gene had been identified as a new oncogene. Aurora Kinase A gene was highly expressed in various malignant tumors, such as oophoroma, colorectal cancer and acute myeloid leukemia [3,4,5]. Aurora Kinase B was highly expressed in many tumor tissues, including oral cancer, the non-small-cell lung carcinoma and hepatocellular carcinoma [6,7,8], etc. It has been showed that the activity inhibitors of Aurora Kinase could inhibit the growth of cancer cells, and some inhibitors have been applied in the pre-clinical experimental stage [9,10]
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