Abstract
We immunocytochemically studied the expression of various epitopes of amyloid ß/A4 protein precursor (APP) after brain damage by kainic acid injection. After 3 h, APP 695 rapidly accumulated in dystrophic neurites near the damaged site. After 3 days, APP with Kunitz-type protease inhibitor domain was expressed in reactive astrocytes in the lesion and ipsilateral hippocampus. APP rapidly accumulated in dystrophic neurites, and different types of APP were expressed in different cell types in the damaged brain.
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